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6
Braz Dent Sci 2023 July/Sept; 26 (3): e3854
Al-Mukhtar YH et al.
Evaluating the efficacy of Etoricoxib in reducing post-operative pain associated with minor oral surgery. A randomized clinical trial
Al-Mukhtar YH et al. Evaluating the efficacy of Etoricoxib in reducing post-operative
pain associated with minor oral surgery. A randomized clinical trial
6. Barden J, Edwards J, Mcquay H, Wiffen PJ, Moore RA. Relative
efficacy of oral analgesics after third molar extraction. Br Dent
J. 2004;197(7):407-11. http://dx.doi.org/10.1038/sj.bdj.4811721.
PMid:15475903.
7. Çebi AT, Kasapoğlu MB, Eren S, Kasapoğlu Ç. Comparison of the
effects of diclofenac potassium and tenoxicam on postoperative
pain, swelling, and trismus following third molar surgery. Turk J
Med Sci. 2018;48(2):271-8. http://dx.doi.org/10.3906/sag-1702-
100. PMid:29714439.
8. Song GG, Seo YH, Kim JH, Choi SJ, Ji JD, Lee YH. Relative
efficacy and tolerability of etoricoxib, celecoxib, and
naproxen in the treatment of osteoarthritis. Z Rheumatol.
2016;75(5):508-16. http://dx.doi.org/10.1007/s00393-015-
0023-9. PMid:26768273.
9. González-Barnadas A, Camps-Font O, Martín-Fatás P, Figueiredo
R, Gay-Escoda C, Valmaseda-Castellón E. Relative efficacy and
safety of selective COX-2 inhibitors for pain management after
third molar removal: a meta-analysis of randomized clinical trials.
Clin Oral Investig. 2020;24(1):79-96. http://dx.doi.org/10.1007/
s00784-019-02910-3. PMid:31016540.
10. Chen L, Yang G, Grosser T. Prostanoids and inflammatory
pain. Prostaglandins Other Lipid Mediat. 2013;104–105:58-66.
http://dx.doi.org/10.1016/j.prostaglandins.2012.08.006.
PMid:22981510.
11. Ji RR, Chamessian A, Zhang YQ. Pain regulation by non-neuronal
cells and inflammation. Science. 2016;354(6312):572-7.
http://dx.doi.org/10.1126/science.aaf8924. PMid:27811267.
12. Grosser T, Theken KN, FitzGerald GA. Cyclooxygenase inhibition:
pain, inflammation, and the cardiovascular system. Clin
Pharmacol Ther. 2017;102(4):611-22. http://dx.doi.org/10.1002/
cpt.794. PMid:28710775.
13. Raffa RB, Ossipov MH, Porreca F. Opioid analgesics and
antagonists. In: Dowd FJ, Johnson BS, Mariotti AJ, editors.
Pharmacology and therapeutics for dentistry. 7th ed. St. Louis:
Elsevier; 2017. p. 241-56. http://dx.doi.org/10.1016/B978-0-323-
39307-2.00016-3.
14. Gordon SM, Brahim JS, Rowan J, Kent A, Dionne RA. Peripheral
prostanoid levels and nonsteroidal anti-inflammatory drug
analgesia: replicate clinical trials in a tissue injury model.
Clin Pharmacol Ther. 2002;72(2):175-83. http://dx.doi.
org/10.1067/mcp.2002.126501. PMid:12189364.
15. Theken KN, Hersh EV, Lahens NF, Lee HM, Li X, Granquist
EJ,etal. Variability in the analgesic response to ibuprofen is
associated with cyclooxygenase activation in inflammatory
pain. Clin Pharmacol Ther. 2019;106(3):632-41. http://dx.doi.
org/10.1002/cpt.1446. PMid:30929268.
16. Vane JR, Botting RM. A better understanding of anti-inflammatory
drugs based on isoforms of cyclooxygenase (COX-1 and COX-2).
Adv Prostaglandin Thromboxane Leukot Res. 1995;23:41-8.
PMid:7537433.
17. Hersh EV, Lally ET, Moore PA. Update of cyclooxygenase
inhibitors: has a third COX isoform entered the fray?
Curr Med Res Opin. 2005;21(8):1217-26. http://dx.doi.
org/10.1185/030079905X56367. PMid:16083531.
18. Stewart M. Etoricoxib for pain and inflammation. Leeds: Egton
Medical Information Systems Limited; 2022.
19. Delgado DA, Lambert BS, Boutris N, McCulloch PC, Robbins AB,
Moreno MR,etal. Validation of digital visual analog scale pain
scoring with a traditional paper-based visual analog scale in
adults. J Am Acad Orthop Surg Glob Res Rev. 2018;2(3):e088.
http://dx.doi.org/10.5435/JAAOSGlobal-D-17-00088.
PMid:30211382.
20. Gould D, Kelly D, Goldstone L, Gammon J. Visual Analogue
Scale (VAS). J Clin Nurs. 2001;10(5):697-706. http://dx.doi.
org/10.1046/j.1365-2702.2001.00525.x. PMid:11822520.
21. Malmstrom K, Sapre A, Couglin H, Agrawal NG, Mazenko
RS, Fricke JR Jr. Etoricoxib in acute pain associated with
dental surgery: a randomized, double blind, placebo- and
active comparator-controlled dose-ranging study. Clin
Ther. 2004;26(5):667-79. http://dx.doi.org/10.1016/S0149-
2918(04)90067-7. PMid:15220011.
22. Vane JR. Inhibition of prostaglandin synthesis as a
mechanism of action for aspirin-like drugs. Nat New
Biol. 1971;231(25):232-5. http://dx.doi.org/10.1038/
newbio231232a0. PMid:5284360.
23. Kara IM, Polat S, İnce MF, Gümüş C. Analgesic and anti-
inflammatory effects of oxaprozin and naproxen sodium
after removal of impacted lower third molars: a randomized,
double blind, placebo controlled crossover study. J Oral
Maxillofac Surg. 2010;68(5):1018-24. http://dx.doi.org/10.1016/j.
joms.2009.09.094. PMid:20206429.
24. Varner J, Lomax M, Blum D, Quessy S. A randomized, controlled,
dose-ranging study investigating single doses of GW406381,
naproxen sodium, or placebo in patients with acute pain after
third molar tooth extraction. Clin J Pain. 2009;25(7):577-
83. http://dx.doi.org/10.1097/AJP.0b013e3181a085fa.
PMid:19692798.
25. Koseoglu BG, Ozturk S, Kocak H, Palanduz S, Cefle K. The
effects of etodolac, nimesulid and naproxen sodium on the
frequency of sister chromatid exchange after enclused third
molars surgery. Yonsei Med J. 2008;49(5):742-7. http://dx.doi.
org/10.3349/ymj.2008.49.5.742. PMid:18972594.
26. Michael HC, Sindet PS, Seymour RA, Hawkesford JE, Coulthard
P, Lamey PJ,etal. Analgesic efficacy of the cyclooxygenase-
inhibiting nitric oxide donor AZD3582 in postoperative
dental pain: comparison with naproxen and rofecoxib in
two randomized, double-blind, placebo-controlled studies.
Clin Ther. 2006;28(9):1279-95. http://dx.doi.org/10.1016/j.
clinthera.2006.09.015. PMid:17062301.
27. Malmstrom K, Kotey P, Coughlin H, Desjardins PJ. A randomized,
double-blind, parallel-group study comparing the analgesic
effect of Etoricoxib to placebo, naproxen sodium, and
acetaminophen with codeine using the dental impaction
pain model. Clin J Pain. 2004;20(3):147-55. http://dx.doi.
org/10.1097/00002508-200405000-00004. PMid:15100590.
28. Cryer B. Nonsteroidal anti-inflammatory drugs and
gastrointestinal disease. In: Feldman M, Scharschmidt
BF, Sleisenger MH, editors. Sleisenger and Fordtran’s
gastrointestinal and liver disease. 6th ed. Philadelphia:
Saunders; 1998. p. 343-57.
29. Mohammed IA, Delemi ZH. Kinesiology tape in comparison
with oral Diclofenac sodium in reducing swelling after
surgical removal of lower wisdom teeth. Al-Rafidain
Dent J. 2019;19(1):90-7. http://dx.doi.org/10.33899/
rden.2020.126364.1008.
30. Leung AT, Malmstrom K, Gallacher AE, Sarembock B, Poor G,
Beaulieu A,etal. Efficacy and tolerability profile of etoricoxib
in patients with osteoarthritis: a randomized, double-blind,
placebo and active-comparator controlled 12-week efficacy
trial. Curr Med Res Opin. 2002;18(2):49-58. http://dx.doi.
org/10.1185/030079902125000282. PMid:12017209.
31. Duarte-Rodrigues L, Miranda EFP, Souza TO, Paiva HN, Falci
SGM, Galvão EL. Third molar removal and its impact on quality
of life: systematic review and meta-analysis. Qual Life Res.
2018;27(10):2477-89. http://dx.doi.org/10.1007/s11136-018-
1889-1. PMid:29797177.
32. Renner B, Zacher J, Buvanendran A, Walter G, Strauss J,
Brune K. Absorption and distribution of etoricoxib in plasma,
CSF, and wound tissue in patients following hip surgery:
a pilot study. Naunyn Schmiedebergs Arch Pharmacol.
2010;381(2):127-36. http://dx.doi.org/10.1007/s00210-009-
0482-0. PMid:20052461.