Multi-omics convergence in odontogenic neoplasm research: a scientometric and translational mapping study

Abstract

Background: Odontogenic tumors (OTs), though rare, pose diagnostic and therapeutic uncertainties due to their heterogeneous behavior. With the advancement of omics technologies like genomics, transcriptomics, proteomics, and metabolomics, molecular understanding of OTs has expanded rapidly. Objective: The aim of this bibliometric analysis is to map literature on omics-driven OT research and evaluate its translational potential in diagnostics, biomarker discovery, and targeted therapy. Material and Methods: A bibliometric analysis of peer-reviewed OT-related omics literature from Scopus databases (until June 2025) was conducted. Tools such as Bibliometrix (R) and VOSviewer were used for network visualization, thematic evolution mapping, and hub gene identification, respectively. Results: Omics-based OT research showed exponential growth post-2010, with transcriptomics leading in recent years. Keyword and thematic analysis revealed an evolution from basic gene discovery to pathway-targeted translational research. Further, bibliometric analysis highlighted important biomarkers such as podoplanin, Cripto-1, and BCL-2 in OTs diagnosis. Conclusion: Multi-omics research in odontogenic tumors (OTs) has shown significant insights for diagnosis and treatment. Advancing this field will require strong cross-disciplinary collaboration and reliable validation methods. Despite the seriousness of OTs, omics-based research in this area is still in its early stages showing there’s a real need and opportunity for more focused and sustained efforts.

KEYWORDS

Bibliometric analysis; Genetic disease; Multi-omics; Neoplasm; Odontogenic tumors.