Effect of alpha amylase on early childhood caries: a matched case-control study
DOI:
https://doi.org/10.14295/bds.2013.v16i1.873Resumo
Objectives: There are a few studies addressing the relationship between salivary alpha-amylase and dental caries. This study was implemented in order to investigate the effect of salivary alpha-amylase level on early childhood caries (ECC).
Materials and Methods: In this matched case-control study, which was carried out from November 2011 to March 2012 in Hamadan City, the west of Iran, mean levels of salivary alpha-amylase of 84 ECC-active cases were compared to that of 84 ECC-free controls using spectrophotometric method to assay enzyme kinetics. The two groups were matched by oral hygiene (frequency of tooth brushing per day) and food habits (frequency of sugar consumption between servings). Subsequently, a subsample of 28 cases was undergone emergency treatment of dental caries. Alpha amylase level was measured before treatment and 30 to 45 minutes later.
Results: The results indicated an inverse relationship between alpha-amylase level and dental caries. The mean level of salivary alpha-amylase was 28.27 and 42.08 kU/L in cases and controls respectively (P=0.001). In addition, emergency treatment of dental caries increased the level of salivary alpha-amylase significantly from 15.05 kU/L before treatment to 23.94 kU/L thereafter (P=0.001) although the level of alpha-amylase did not reach the normal level of ECC-free controls
Conclusion: Generally it can be concluded that low levels of alpha-amylase may promote early childhood caries. On the other hand, dental caries may subsequently reduce the level of salivary alpha-amylase. This vicious cycle may promote and then accelerate caries formation among susceptible people with low level of salivary alpha-amylase.
Downloads
Downloads
Publicado
Como Citar
Edição
Seção
Licença
TRANSFERÊNCIA DE DIREITOS AUTORAIS E DECLARAÇÃO DE RESPONSABILIDADE
Toda a propriedade de direitos autorais do artigo "____________________________________________________________________" é transferido do autor(es) para a CIÊNCIA ODONTOLÓGICA BRASILEIRA, no caso do trabalho ser publicado. O artigo não foi publicado em outro lugar e não foi submetido simultaneamente para publicação em outra revista.
Vimos por meio deste, atestar que trabalho é original e não apresenta dados manipulados, fraude ou plágio. Fizemos contribuição científica significativa para o estudo e estamos cientes dos dados apresentados e de acordo com a versão final do artigo. Assumimos total responsabilidade pelos aspectos éticos do estudo.
Este texto deve ser impresso e assinado por todos os autores. A versão digitalizada deverá ser apresentada como arquivo suplementar durante o processo de submissão.