Evaluation of the antifungal activity of plant extracts and oral antiseptics against Candida albicans

Authors

  • Roberta Carvalho Sthel Balliana Laboratory of Medical Mycology – Department of Pathology – Federal University of Espirito Santo (Universidade Federal do Espírito Santo – UFES) – ES – Brazil.
  • Cláudia Masrouah Jamal Department of Pharmaceutical Sciences – Federal University of Espirito Santo (UFES) – ES – Brazil.
  • Simone Bravim Maifrede Laboratory of Medical Mycology – Department of Pathology – Federal University of Espirito Santo (Universidade Federal do Espírito Santo – UFES) – ES – Brazil.
  • Mariceli Lamas de Araújo Laboratory of Medical Mycology – Department of Pathology – Federal University of Espirito Santo (Universidade Federal do Espírito Santo – UFES) – ES – Brazil.

DOI:

https://doi.org/10.14295/bds.2014.v17i4.1044

Abstract

Objective: Oral candidiasis is the most common fungal infection of the oral cavity, and Candida albicans is the most frequently isolated species. Material and Methods: In this study, the potential antifungal effect of extracts from Gossypium hirsutum L., Arctium lappa, Equisetum sp., Cecropia pachystachya Trécul and Pogostemon heyneanus plants were evaluated on non-adhered cells of C. albicans, and the effect of oral antiseptics A (cetylpyridinium chloride 0.500 mg), B (chlorhexidine gluconate 0.12%), C (hydrogen peroxide 1.5%) and D (thymol, eucalyptol, menthol and methyl salicylate) were evaluated on non-adhered cells and biofilms of C. albicans, using turbidimetry and minimal inhibitory concentration (MIC) of the extracts and the maximal inhibitory dilution (MID) of the antiseptics. Results: The most promising results on non-adhered cells were obtained with Cecropia pachystachyaTrécul extracts, with MIC values between 7.81 and 3.91 µg/mL. Antiseptics A and B showed the lowest MID values, between 0.20 and 0.10% (Kruskal-Wallis, p<0.0001). Regarding biofilm inhibition, the MID values found were similar for the tested antiseptics, varying from 50% to 0.20% (Kruskal-Wallis, p=0.6915). Conclusion: These results show that some plant extracts has potential use in the prevention and treatment of oral candidiasis. 

Author Biography

Roberta Carvalho Sthel Balliana, Laboratory of Medical Mycology – Department of Pathology – Federal University of Espirito Santo (Universidade Federal do Espírito Santo – UFES) – ES – Brazil.

Departamento de Patologia

Laboratorio de Micologia

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Published

2014-11-03

Issue

Vol. 17 No. 4 (2014): Oct. - Dec. / 2014 - Published November 2014

Section

Clinical or Laboratorial Research