Evaluation of the antifungal activity of plant extracts and oral antiseptics against Candida albicans

Authors

  • Roberta Carvalho Sthel Balliana Laboratory of Medical Mycology – Department of Pathology – Federal University of Espirito Santo (Universidade Federal do Espírito Santo – UFES) – ES – Brazil.
  • Cláudia Masrouah Jamal Department of Pharmaceutical Sciences – Federal University of Espirito Santo (UFES) – ES – Brazil.
  • Simone Bravim Maifrede Laboratory of Medical Mycology – Department of Pathology – Federal University of Espirito Santo (Universidade Federal do Espírito Santo – UFES) – ES – Brazil.
  • Mariceli Lamas de Araújo Laboratory of Medical Mycology – Department of Pathology – Federal University of Espirito Santo (Universidade Federal do Espírito Santo – UFES) – ES – Brazil.

DOI:

https://doi.org/10.14295/bds.2014.v17i4.1044

Abstract

Objective: Oral candidiasis is the most common fungal infection of the oral cavity, and Candida albicans is the most frequently isolated species. Material and Methods: In this study, the potential antifungal effect of extracts from Gossypium hirsutum L., Arctium lappa, Equisetum sp., Cecropia pachystachya Trécul and Pogostemon heyneanus plants were evaluated on non-adhered cells of C. albicans, and the effect of oral antiseptics A (cetylpyridinium chloride 0.500 mg), B (chlorhexidine gluconate 0.12%), C (hydrogen peroxide 1.5%) and D (thymol, eucalyptol, menthol and methyl salicylate) were evaluated on non-adhered cells and biofilms of C. albicans, using turbidimetry and minimal inhibitory concentration (MIC) of the extracts and the maximal inhibitory dilution (MID) of the antiseptics. Results: The most promising results on non-adhered cells were obtained with Cecropia pachystachyaTrécul extracts, with MIC values between 7.81 and 3.91 µg/mL. Antiseptics A and B showed the lowest MID values, between 0.20 and 0.10% (Kruskal-Wallis, p<0.0001). Regarding biofilm inhibition, the MID values found were similar for the tested antiseptics, varying from 50% to 0.20% (Kruskal-Wallis, p=0.6915). Conclusion: These results show that some plant extracts has potential use in the prevention and treatment of oral candidiasis. 

Author Biography

Roberta Carvalho Sthel Balliana, Laboratory of Medical Mycology – Department of Pathology – Federal University of Espirito Santo (Universidade Federal do Espírito Santo – UFES) – ES – Brazil.

Departamento de Patologia

Laboratorio de Micologia

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Published

2014-11-03

Issue

Vol. 17 No. 4 (2014): Oct. - Dec. / 2014 - Published November 2014

Section

Clinical or Laboratorial Research

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All manuscript's copyright ownership of the article "____________________________________________________________________" is transferred from the author(s) to the BRAZILIAN DENTAL SCIENCE, in the event the work is published. The manuscript has not been published elsewhere and that it has not been submitted simultaneously for publication elsewhere.

We hereby attest the study is original and does not present manipulated data, fraud or plagiarism. We made significant scientific contribution to the study and we are aware of the presented data and in agreement with the final version of the manuscript. We assume complete responsibility for the ethical aspects of the study.

 

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