The influence of early bisphosphonate treatment on craniofacial radiographic bone density

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DOI:

https://doi.org/10.14295/bds.2019.v22i4.1747

Abstract

Objective: To evaluate the effects of alendronate (AL), a bisphosphonate, on visual bone density by means of a radiographic analysis. Material and methods: Sixty-two Wistar rats were divided into four groups: Group AA (AL with autogenous graft); group AW (AL without autogenous graft) both receiving AL on alternate days for 4 weeks before surgery; control group CA (with autogenous graft); group CW (without autogenous graft) both receiving saline solution before surgery. Experimental periods of evaluation were 2 weeks and 4 weeks post-surgery. Conventional and digital radiographs were obtained, and a 5-point grading system (score) was used to assess visual radiographic bone density. Results: There were no statistical differences between CA and AA groups at 2 and 4 weeks. The AA group had a higher mean score of bone density than the CW and AW groups at 2 weeks (P < 0.05). The CA and AA groups had higher scores of bone density than the CW and AW groups at 4 weeks (P < 0.05). Conclusions: Treatment with AL did not affect radiographic bone density at 2 and 4 weeks after surgery. The presence of an autograft resulted in higher scores of bone density.

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Author Biography

Melissa Rodrigues Araujo, Universidade Federal do Paraná

Departamento de Estomatologia

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Published

2019-10-31

How to Cite

1.
Araujo MR, Mobile RZ, Azevedo L de O, Gomes S, Deliberador TM, Giovanini AF. The influence of early bisphosphonate treatment on craniofacial radiographic bone density. BDS [Internet]. 2019 Oct. 31 [cited 2025 Aug. 21];22(4):513-9. Available from: https://ojs.ict.unesp.br/index.php/cob/article/view/1747

Issue

Vol. 22 No. 4 (2019): Oct. - Dec. / 2019 - Published October 2019

Section

Clinical or Laboratorial Research

License

Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.

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