Microbiological evaluation for antifungal activity of some metal oxides nanofillers incorporated into cold cured soft lining materials: clinical based study
DOI:
https://doi.org/10.4322/bds.2022.e2921Abstract
Objective: The aim of the current study was to evaluate the efficacy of addition of zirconium oxide (ZrO2), titanium oxide
(TiO2), and silica oxide (SiO2) nanoparticles to cold-cured soft liner on adhesion of Candida albicans (CA). Material and
Methods: Fifty-four patients had been selected and divided into three groups according to the modification of soft liner
with ZrO2, TiO2, and SiO2 nanoparticles (18 each of). Each patient received maxillary complete denture having three
cavities, the cavities were lined using cold cured soft liner modified with different concentration (0%, 3%, and 7%) of
metal oxide nanoparticles. On days 14 and 28, swaps were taken out from relining site and immediately cultured for
fungal evaluation. The number of colonies were counted, data collected and explored for normality using Shapiro-Wilk
test, logarithmic transformation of CA count was performed. Repeated and one-way ANOVA were used followed by
Tukey HSD. Independent-t test used to compare between CA counts at different periods. Results: The CA adhesion
was significantly decreased by the addition of ZrO2, TiO2 and SiO2 nanoparticles in comparison with control group, also
the antifungal coverage increased with nanoparticles concentration increased (P<0.005). The highest CA count was
identified in group SiO2 followed by ZrO2, while TiO2 showed the lowest CA count (P <0.001). Conclusion: Addition
of different nanoparticles; ZrO2, TiO2 and SiO2 to cold-cured soft liner is an effective method for reducing CA adhesion.
KEYWORDS
Antifungal agent; Candida albicans; Denture liners; Nanoparticles.
Downloads
Downloads
Published
Versions
- 2022-03-29 (2)
- 2022-03-18 (1)
How to Cite
Issue
Section
License
Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.
=================
COPYRIGHT TRANSFER AND RESPONSIBILITY STATEMENT
(PDF)
For all articles published in the BDS journal, copyright is retained by the authors. Articles are licensed under an open-access Creative Commons CC BY 4.0 license, meaning that anyone may download and read the paper for free. In addition, the article may be reused and quoted, provided that the original published version is cited. These conditions allow for maximum use and exposure of the work while ensuring that the authors receive proper credit. All metadata associated with published articles is released under the Creative Commons CC0 Universal Public Domain Dedication.
Before the submission, authors must obtain permission to reproduce any published material (figures, schemes, tables, or any extract of a text) that does not fall into the public domain or for which they do not hold the copyright. Permission should be requested by the authors from the copyright holder (usually the Publisher, please refer to the imprint of the individual publications to identify the copyright holder).
The authors hereby attest that the study is original and does not present manipulated data, fraud, or plagiarism. All names listed made a significant scientific contribution to the study, are aware of the presented data, and agree with the final version of the manuscript. They assume complete responsibility for the ethical aspects of the study.
This text must be printed and signed by all authors. The scanned version should be submitted as supplemental file during the submission process.
