Genetic variants of vitamin-D receptor genome and teeth caries susceptibility in Iraqi children
DOI:
https://doi.org/10.4322/bds.2024.e4184Abstract
Objective: To find out if there is a link between the TaqI, ApaI, BsmI, and FokI polymorphisms of the vitamin D receptor (VDR) and dental caries risk in Iraqi children. Material and Methods: The study had a sample of one hundred children, consisting of fifty males and fifty females, their mean age of 10.2 ± 1.21 years old. The study volunteers were categorized into two groups: a moderate caries risk group (DMFT, 1-4) consisting of 50 individuals, and a caries-free group including 50 individuals. Salivary samples were obtained from each participant, and subsequent DNA extraction was performed. The VDR gene was geno-typed using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques. All data were subjected to statistical analysis using the chi square test, Fisher’s exact test, and Odds ratios; results considered significant when (P<0.05). Results: A statistically significant difference was seen in the frequency of FokI genotypes (CC) between children with caries and those without caries (P<0.05). Individuals possessing the (CC) genotype had a 2.745-fold higher probability of being susceptible to dental caries with CI 95% of (1.077 - 6.996). While there were no significant differences (P>0.05) found between the TaqI, ApaI, and BsmI genotypes and cavities in the teeth. Conclusion: FokI (rs2228570) polymorphisms of the vitamin D receptor (VDR) showed an association with dental caries. VDR genetic variants may be employed in the future as a potential marker for identifying people at risk for caries when paired with environmental variables, as well as for caries prevention and treatment.
KEYWORDS
Caries; Gene; Genetic; Polymorphism; Vitamin D.
Downloads
Published
How to Cite
Issue
Section
License
Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.
=================
COPYRIGHT TRANSFER AND RESPONSIBILITY STATEMENT
(PDF)
For all articles published in the BDS journal, copyright is retained by the authors. Articles are licensed under an open-access Creative Commons CC BY 4.0 license, meaning that anyone may download and read the paper for free. In addition, the article may be reused and quoted, provided that the original published version is cited. These conditions allow for maximum use and exposure of the work while ensuring that the authors receive proper credit. All metadata associated with published articles is released under the Creative Commons CC0 Universal Public Domain Dedication.
Before the submission, authors must obtain permission to reproduce any published material (figures, schemes, tables, or any extract of a text) that does not fall into the public domain or for which they do not hold the copyright. Permission should be requested by the authors from the copyright holder (usually the Publisher, please refer to the imprint of the individual publications to identify the copyright holder).
The authors hereby attest that the study is original and does not present manipulated data, fraud, or plagiarism. All names listed made a significant scientific contribution to the study, are aware of the presented data, and agree with the final version of the manuscript. They assume complete responsibility for the ethical aspects of the study.
This text must be printed and signed by all authors. The scanned version should be submitted as supplemental file during the submission process.
