Histomorphometric, radiographic and biomechanical analyses of platelet rich plasma associated with autogenous bone graft

Authors

  • Adriana Socorro Ferreira Monteiro Bioscience Center for Special Health Care Needs (CEBAPE) – School of Dentistry – Institute of Science and Technology – UNESP – Univ Estadual Paulista – São José dos Campos – SP – Brazil.
  • Nelson Luiz Macedo Department of Diagnosis and Surgery – School of Dentistry – Institute of Science and Technology – UNESP – Univ Estadual Paulista – São José dos Campos – SP – Brazil.
  • Luiz Guilherme Scavone Macedo Department of Dental Materials and Prosthodontics – School of Dentistry – Institute of Science and Technology – UNESP – Univ Estadual Paulista – São José dos Campos – SP – Brazil.
  • Rosilene Fernandes Rocha Department of Dental Materials and Prosthodontics – School of Dentistry – Institute of Science and Technology – UNESP – Univ Estadual Paulista – São José dos Campos – SP – Brazil.

DOI:

https://doi.org/10.14295/bds.2014.v17i4.998

Abstract

Objective: The aim of this study was to evaluate the effectiveness of platelet rich plasma with and without autogenous bone graft in the bone repair of surgical defects in rabbit tibias. Materials and Methods: In this research, 25 adult male rabbits were used. Two defects have been performed in each tibia, divided into four groups: control (C = defect naturally left to heal by clot formation), autogenous (A = bone defect + autogenous graft), PRP (PRP = bone defect + PRP) and autogenous + PRP (PRPA = bone defect + autogenous graft + PRP). All the defects were covered with a dPTFE membrane. Five other animals were sacrificed at 15, 30, and 60-day postoperatively. The pieces containing the defects were processed for histological and histomorphometric analysis. Other five animals were sacrificed after 30 and 60 days and submitted to biomechanical analysis, and all the specimens were sent to the radiographic evaluation of optical density. Results: The biomechanical, radiographic, and histomorphometric results showed larger resistance, optical density, and improving bone formation in the groups A and PRPA when compared with the groups C and PRP. Conclusion: This study showed there was not an improvement in the radiographic, mechanical, and bone formation parameters when PRP was used individually or associated to the autogenous bone graft.

Downloads

Download data is not yet available.

Downloads

Additional Files

Published

2014-11-03

How to Cite

1.
Monteiro ASF, Macedo NL, Macedo LGS, Rocha RF. Histomorphometric, radiographic and biomechanical analyses of platelet rich plasma associated with autogenous bone graft. BDS [Internet]. 2014 Nov. 3 [cited 2025 Aug. 21];17(4):53-64. Available from: https://ojs.ict.unesp.br/index.php/cob/article/view/998

Issue

Vol. 17 No. 4 (2014): Oct. - Dec. / 2014 - Published November 2014

Section

Clinical or Laboratorial Research

License

Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.

=================

COPYRIGHT TRANSFER AND RESPONSIBILITY STATEMENT
 (PDF)

For all articles published in the BDS journal, copyright is retained by the authors. Articles are licensed under an open-access Creative Commons CC BY 4.0 license, meaning that anyone may download and read the paper for free. In addition, the article may be reused and quoted, provided that the original published version is cited. These conditions allow for maximum use and exposure of the work while ensuring that the authors receive proper credit. All metadata associated with published articles is released under the Creative Commons CC0 Universal Public Domain Dedication.

Before the submission, authors must obtain permission to reproduce any published material (figures, schemes, tables, or any extract of a text) that does not fall into the public domain or for which they do not hold the copyright. Permission should be requested by the authors from the copyright holder (usually the Publisher, please refer to the imprint of the individual publications to identify the copyright holder).

The authors hereby attest that the study is original and does not present manipulated data, fraud, or plagiarism. All names listed made a significant scientific contribution to the study, are aware of the presented data, and agree with the final version of the manuscript. They assume complete responsibility for the ethical aspects of the study.

This text must be printed and signed by all authors. The scanned version should be submitted as supplemental file during the submission process.

Most read articles by the same author(s)