Resveratrol as adjuvant of non-surgical periodontitis treatment: a systematic review and meta-analysis

Abstract

Objective: This systematic review aims to raise evidence on the effectiveness of the use of resveratrol supplementation (RV) as an adjuvant therapy for scaling and root planning in the treatment of periodontitis. Material and Methods: This review followed the Preferred Reporting Items for Systematic Reviews and Meta- Analysis Guidelines (PRISMA) and was registered in the International Database of Systematic Reviews (PROSPERO CRD42024507782). PubMed/MEDLINE, Scopus, Embase, and Cochrane Library were searched through October 2024. The PICO question was: “Is the resveratrol supplementation effective as an adjuvant therapy of non-surgical periodontitis disease treatment?”. The established inclusion criteria were: 1) randomized controlled clinical trials (RCTs), 2) a minimum of 15 patients with periodontitis disease, and 3) follow-up of at least 4 weeks. The minimum follow-up duration was 4 weeks. Results: After searching the identified databases, 166 were screened and 3 were selected for full reading. Therefore, 3 studies were included in the final analysis. The total number of participants included in the control group (placebo) was 82, while in the intervention group (RV) was 160, with a mean age of 38 years. Conclusion: Despite the limitations of the number of studies included in this systematic review, resveratrol supplementation as an adjuvant to non-surgical periodontal therapy could contribute to optimizing the treatment of periodontitis.

KEYWORDS

Periodontal diseases; Periodontitis; Phytoestrogens; Resveratrol; Systematic review.