Surgical treatment of osteonecrosis associated with bisphosphonates: a case report

Authors

  • Luisa Machado Barin Department of Pathology – Federal University of Santa Maria – Santa Maria – RS – Brazil.
  • Fernanda Maia Pillusky Department of Pathology – Federal University of Santa Maria – Santa Maria – RS – Brazil.
  • Raquel Cristine Silva Barcelos Department of Physiology and Pharmacology – Federal University of Santa Maria – Santa Maria – RS – Brazil.
  • Carlos Alberto Bazaglia Escobar Department of Stomatology – Federal University of Santa Maria – Santa Maria – RS – Brazil.
  • Cristiane Cademartori Danesi Department of Pathology – Federal University of Santa Maria – Santa Maria – RS – Brazil.

DOI:

https://doi.org/10.14295/bds.2017.v20i3.1362

Abstract

Bisphosphonates (BP) are routinely used in the management of metastatic bone diseases and malignancies neoplasms, but there is an adverse effect of their chronic use called bisphosphonate-related osteonecrosis of the jaw (BRONJ). Treatment for BRONJ is challenging and complex, as there is still no definitive treatment protocols and the various treatments described in the literature have success variables indexes. In this sense, this study aims to emphasize the responsibility of dentist about the knowledge of BRONJ and report a clinical case that the surgical therapy was the best treatment option. Male patient, sixty-nine years old, asked for dental care complaining about bone exposure. On the anamneses, he reported the use of BP due to cancer history. The intra oral examination revealed exposed bone in the lower right molar region extending to retromolar trigon region on lingual side. There was conservative treatment with antibiotic therapy and mouth rinses of chlorhexidine 0.12 %, but not obtaining success. Therefore, we opted for the surgical removal of necrotic bone area and the tooth involved. The postoperative was within normal standard. The knowledge of dentist about this pathology is essential to prevent, diagnose and treat this disease the most appropriate way. Although the treatment of BRONJ remains challenging and complex, surgical therapy is a treatment option for lesions in early clinical stages and resistant to conservative treatment, providing a better prognosis and quality of life for the patient.

 

Keywords

Bisphosphonate-associated osteonecrosis; Mandible; Oral surgical procedures.

Author Biographies

Luisa Machado Barin, Department of Pathology – Federal University of Santa Maria – Santa Maria – RS – Brazil.

Departamento de Patologia, Universidade Federal de Santa Maria

Fernanda Maia Pillusky, Department of Pathology – Federal University of Santa Maria – Santa Maria – RS – Brazil.

Department of Pathology, Federal University of Santa Maria, Santa Maria/RS

Postgraduate Program in Dental Science

Raquel Cristine Silva Barcelos, Department of Physiology and Pharmacology – Federal University of Santa Maria – Santa Maria – RS – Brazil.

Department of Phisiology and Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil

Ph.D.

Carlos Alberto Bazaglia Escobar, Department of Stomatology – Federal University of Santa Maria – Santa Maria – RS – Brazil.

Department of Stomatology, Federal University of Santa Maria, Santa Maria/RS

Ph.D.

Cristiane Cademartori Danesi, Department of Pathology – Federal University of Santa Maria – Santa Maria – RS – Brazil.

Department of Pathology, Federal University of Santa Maria, Santa Maria/RS

Ph.D.

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Published

2017-09-12

Issue

Section

Case Report or Clinical Technique