Altered levels of inhibitory cytokines in patients with thalassemia major and gingival inflammation

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DOI:

https://doi.org/10.14295/bds.2019.v22i3.1708

Abstract

Objective: To evaluate local and systemic levels of interleukin-10 (IL-10), IL-33, and tumor necrosis factor alpha (TNF-?) in Thalassemia major (TM) in the presence of gingival inflammation. Material and Methods: 58 patients (TM, n=29 and systemically healthy controls, n=29) were included to the study. IL-10, IL-33, and TNF-? levels were evaluated in gingival crevicular fluid (GCF), saliva and serum. Clinical periodontal measurements were recorded. Results: GCF IL-33 total amounts in TM and gingivitis group were elevated compared to systemically and periodontally healthy group (p=0.01). GCF IL-10, IL-33 and TNF-? concentrations were higher in TM and periodontally healthy group than the systemically healthy and gingivitis group (p=0.02, p=0.008, p=0.003). Serum IL-10 levels were elevated in TM and gingivitis compared to the systemically healthy and gingivitis (p=0.0009) and systemically and periodontally healthy (p=0.0007) groups. Serum IL-10 and TNF-? levels in TM and periodontally healthy group were higher than systemically and periodontally healthy group (p=0.01 and p=0.02). Conclusion: TM may potentially alter circulating levels of IL-33 and IL-10 and therefore, may affect the degree of periodontal inflammation locally or vice versa. Yet, the underlying mechanism linking the hematologic condition is not clear and deserves further investigation.

 

Keywords

Gingivitis; Thalassemia major; Interleukin-10; Interleukin-33; Tumor Necrosis Factor-alpha.

 

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Published

2019-07-30

How to Cite

1.
Akcalı A, Kahraman Çeneli S, Meriç P, Nalbantsoy A, Ozçaka Özgün, Buduneli N. Altered levels of inhibitory cytokines in patients with thalassemia major and gingival inflammation. BDS [Internet]. 2019 Jul. 30 [cited 2025 Aug. 21];22(3):349-57. Available from: https://ojs.ict.unesp.br/index.php/cob/article/view/1708

Issue

Vol. 22 No. 3 (2019): Jul. - Sep. / 2019 - Published July 2019

Section

Clinical or Laboratorial Research

License

Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.

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