Experimental candidosis on rat’s tongue
DOI:
https://doi.org/10.14295/bds.2004.v7i2.484Abstract
The purpose of this study was to evaluate the development of candidosis in rat’s tongue after intraepithelialinjections of Candida albicans. Fifty rats (Rattus norvegicus, Albinus, Wistar), originally negative for the Candidaspp. received ten intraepithelial injections of C. albicans on the dorsal tongue. Groups of five animals werekilled after 1, 2, 4, 6, 8, and 12 hours and 1, 2, 7, and 15 days after the injection. The rat’s tongues weresurgically removed and then macroscopic and microscopic analyses were performed. The development of candidosislesions was observed in all the rats studied. One hour after the injection, the development of germ tubesfrom the yeast cells could be observed. After 4 hours, Candida spp. pseudohyphae penetrated the epithelial cellswith the formation of microabscesses. After 24 to 48 hours, the epithelial areas with pseudohyphae invasionpresented desquamation, hyperplasia of the basal layer and discrete inflammation of the connective tissue. Afterseven days, few pseudohyphae could be observed. The epithelium presented acanthosis, hyperkeratosis and lossof filiform papillae. After 15 days, neither yeasts nor pseudohyphae were found. In some areas, the epitheliumpresented acanthosis and loss of filiform papillae. It can be concluded that the intraepithelial injection of Candidaalbicans on the dorsal rat tongue caused candidosis lesions in all the animals studied. C. albicans waspresent until seven days after the injections.Downloads
Downloads
Published
How to Cite
Issue
Section
License
Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.
=================
COPYRIGHT TRANSFER AND RESPONSIBILITY STATEMENT
(PDF)
For all articles published in the BDS journal, copyright is retained by the authors. Articles are licensed under an open-access Creative Commons CC BY 4.0 license, meaning that anyone may download and read the paper for free. In addition, the article may be reused and quoted, provided that the original published version is cited. These conditions allow for maximum use and exposure of the work while ensuring that the authors receive proper credit. All metadata associated with published articles is released under the Creative Commons CC0 Universal Public Domain Dedication.
Before the submission, authors must obtain permission to reproduce any published material (figures, schemes, tables, or any extract of a text) that does not fall into the public domain or for which they do not hold the copyright. Permission should be requested by the authors from the copyright holder (usually the Publisher, please refer to the imprint of the individual publications to identify the copyright holder).
The authors hereby attest that the study is original and does not present manipulated data, fraud, or plagiarism. All names listed made a significant scientific contribution to the study, are aware of the presented data, and agree with the final version of the manuscript. They assume complete responsibility for the ethical aspects of the study.
This text must be printed and signed by all authors. The scanned version should be submitted as supplemental file during the submission process.
