Histomorphometric analysis of the effects of calcitonin on alveolar socket repair in diabetic rats
DOI:
https://doi.org/10.14295/bds.2012.v15i2.763Keywords:
alvéolo dentário, calcitonina de salmão, diabetes mellitus, estreptozotocina, reparação do ossoAbstract
O objetivo desse estudofoi fazer uma avaliação histomorfométrica da cicatrização do alvéolo dental na presença crónica de calcitonina de salmão (16UI/Kg) na condição do diabetes. Para isso sessenta ratos albinos foram utilizados. Estes animais foram divididos em três grupos: controle (C), diabético (D) e diabéticos tratados com calcitonina(Dca). Os grupos D e Dca receberam uma injeção única 45mg/Kg intraperitoneal de estreptozotocina-STZ. Após duas semanas, todos os animais foram submetidos a exodontia do incisivo superior direito e cinco animais de cada grupo foram sacrificados aos 15, 30 e 45 dias pós-operatórios. As peças foram fixadas, descalcificados e incluídas em parafina. Os blocos obtidos foram cortados com 6 micrômetros de espessura e corados com hematoxilina e eosina para estudo morfológico. De acordo com os resultados obtidos verificou-se que nos animais tratados com calcitonina houve alteração na cicatrização da ferida após extração dental, atenuando o comprometimento da dinâmica da reparação óssea comumente observada no estado diabético.
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- diego, Figure 1- Control group with 15 days.tif (Português (Brasil))
- diego, Figure 2 - Diabetic group with 15 days.tif (Português (Brasil))
- diego, Figure 3 - Group diabetic+calcitonin with 15 days.tif (Português (Brasil))
- diego, Figure 4- Control group with 45 days.tif (Português (Brasil))
- diego, Figure 5- Diabetic group with 45 days.tif (Português (Brasil))
- diego, Figure 6 - Group diabetic+calcitonin with 45 days.tif (Português (Brasil))
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