Preventive and therapeutic effects of relaxin on bisphosphonaterelated osteonecrosis of the jaw: an experimental study in rats

Autores

DOI:

https://doi.org/10.14295/bds.2020.v23i1.1846

Resumo

Objective: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a challenging complication of chronic bisphosphonate (BP) use. The hormone relaxin is able to induce the multistep differentiation process of human osteoclastogenesis, exhibits anti-fibrotic and anti-inflammatory actions, and promotes vasodilatation, wound healing, and angiogenesis. The present study aimed to evaluate the effects of relaxin in the prevention and management of BRONJ. Material and Methods: Thirty-six male Sprague Dawley rats were randomly divided into four groups. Rats in group 1 (n = 10) received relaxin and BP simultaneously for 12 weeks. Rats in group 2 (n = 10) received injections of BP for 12 weeks, followed by relaxin for another 12 weeks. Rats in group 3 (n = 10) received only BP injections, and those in group 4 (control, n = 6) received only saline. Necrosis and inflammation in the rats’ mandibles were evaluated as indicators of BRONJ. Results: Necrosis and inflammation were not detected in group 1 (BP + relaxin). In group 3 (BP only), incidence rates of necrosis and inflammation were 90% and 60%, respectively. Conclusions: Our findings suggest that relaxin may be potently effective in preventing BRONJ and have some benefit in the treatment of existing BRONJ.

KEYWORDS

Animal model; BRONJ; Relaxin.

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Biografia do Autor

Tuba Develi, Istanbul Medipol University - Department of Oral and Maxillofacial Surgery - İstanbul - Turkey.

department of oral and maxillofacial surgery

Sina Uckan, Istanbul Medipol University - Department of Oral and Maxillofacial Surgery - İstanbul - Turkey.

department of oral and maxillofacial surgery

Burak Bayram, Baskent University - Department of Oral and Maxillofacial Surgery - Ankara - Turkey.

department of oral and maxillofacial surgery

Kagan Deniz, Istanbul Baskent University - Department of Oral and Maxillofacial Surgery - Istanbul - Turkey

department of oral and maxillofacial surgery

Remzi Saban Erdem, Baskent University Medical Faculty - Department of Pharmacology - Ankara - Turkey.

Department of Pharmacology

Hannan Binnaz Ozdemir, Baskent University Medical Faculty - Department of Pathologhy - Ankara - Turkey

Department of Pathologhy

Neslihan Bascil Tutuncu, Baskent University Medical Faculty - Department of Endocrinologhy - Ankara - Turkey

Department of Endocrinologhy

Didem Bacanli, Baskent University Medical Faculty - Experimental Animals Breeding and Research Center - Ankara - Turkey.

Experimental Animals Breeding and Research Center

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Publicado

2020-01-31

Como Citar

1.
Develi T, Uckan S, Bayram B, Deniz K, Erdem RS, Ozdemir HB, Tutuncu NB, Bacanli D. Preventive and therapeutic effects of relaxin on bisphosphonaterelated osteonecrosis of the jaw: an experimental study in rats. BDS [Internet]. 31º de janeiro de 2020 [citado 6º de setembro de 2025];23(1):6 p. Disponível em: https://ojs.ict.unesp.br/index.php/cob/article/view/1846

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Seção

Artigos de Pesquisa Clínica ou Laboratorial