Insights on the role of cytokines in carious lesions

Authors

  • Lucelia Lemes Goncalves Universidade Estadual de Sao Paulo, Instituto de Ciencias e Tecnologia de Sao Jose dos Campos, Departamento de Dentistica Restauradora, Sao Jose dos Campos, SP, Brasil. https://orcid.org/0000-0002-1973-5854
  • Eui Kim University of Toronto, Faculty of Dentistry, Restorative Department, Toronto, Ontario, Canada.
  • Janaina Freitas Bortolatto University of Toronto, Faculty of Dentistry, Restorative Department, Toronto, Ontario, Canada. https://orcid.org/0000-0002-6584-7136
  • Marilia Rabello Buzalaf Universidade de Sao Paulo, Faculdade de Odontologia de Bauru, Departamento de Ciencias Biologicas, Bauru, SP, Brasil. https://orcid.org/0000-0002-5985-3951
  • Lulwah Alreshaid King Saud bin Abdulaziz University for Health Sciences, College of Dentistry, Department of Restorative Dental Sciences, Riyadh, Saudi Arabia. https://orcid.org/0000-0002-7354-9526
  • Anuradha Prakki University of Toronto, Faculty of Dentistry, Restorative Department, Toronto, Ontario, Canada. https://orcid.org/0000-0002-8969-9043

DOI:

https://doi.org/10.4322/bds.2023.e3666

Abstract

Objectives: The dentin-pulp immune response to caries pathogenesis is still poorly understood due to the complex
interplay of the involving processes. The aim of this review was to explore the role of cytokines and its relevance in
the pathogenesis of dental caries. Results: Dental caries can result in a host inflammatory response in the dental
pulp, characterized by the accumulation of inflammatory cells leading to the release of inflammatory cytokines
such as Interleukin-4 (IL-4), Interleukin (IL-6), Interleukin-8 (IL-8) and Tumor necrosis factor–a (TNF-a). IL-4
seems to be correlated to the depth of carious lesions; IL-6 is strongly correlated to caries disease and is considered
a potent biomarker; IL-8 can be a potent biomarker for both caries and other changes present in the pulp and,
its release is correlated to TNF-a and IL-6; TNF-a plays an important role not only in caries progression, but also
in other pathological processes. Conclusion: Specific mediators have a great potential to serve as biomarkers
alluding to the presence and progress of caries disease, urging further investigations in the field.


KEYWORDS
Biomarkers; Cytokines; Dental caries; Dental pulp; Interleukins.

Author Biography

Anuradha Prakki, University of Toronto, Faculty of Dentistry, Restorative Department, Toronto, Ontario, Canada.

 

Birth: 26 March 1975

1996: BDS, Campinas State University, Piracicaba, Brazil

2000: Specialty Program in Restorative Dentistry, University of Sao Paulo, Bauru, Brazil

2002: MSc in Restorative Dentistry, University of Sao Paulo, Bauru, Brazil

2006: Research Scholar, University of North Carolina, Chapel Hill, USA

2007: PhD in Biomaterials, University of Sao Paulo, Bauru, Brazil

2008-2014: Assistant Professor, University of Toronto, Faculty of Dentistry, Canada

2014: Visiting Researcher, College of Dental Medicine, Georgia Regents University, Augusta, USA

2014-Present: Associate Professor, University of Toronto, Faculty of Dentistry, Canada

 

Dr. Prakki is member of IADR (International Association for Dental Research) and ADM (Academy of Dental Materials); She has published 50+ per-reviewed articles in international journals, and has received important teaching awards including the Bruce Hord Master Teacher Award (University of Toronto, faculty of Dentistry) and W.W. Wood Award (Association of Canadian Faculties of Dentistry).

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Published

2023-01-27

Issue

Vol. 26 No. 1 (2023): Jan - Mar / 2023 - Published Jan 2023

Section

Literature Review Manuscript