Estrogen treatment and periodontal disease progression: an experimental study in ovariectomized rats

Authors

  • Marianne Spalding Univ Estadual Paulista “Júlio de Mesquita Filho” – Campus of São José dos Campos, SP, Brazil
  • Priscila Ferreira Amschilnger Univ Estadual Paulista “Júlio de Mesquita Filho” – Campus of São José dos Campos, SP, Brazil
  • Marcela Almeida Prado Univ Estadual Paulista “Júlio de Mesquita Filho” – Campus of São José dos Campos, SP, Brazil
  • Ivan Balducci Univ Estadual Paulista “Júlio de Mesquita Filho” - Campus of São José dos Campos, SP, Brazil
  • Yasmin Rodarte Carvalho Univ Estadual Paulista “Júlio de Mesquita Filho” – Campus of São José dos Campos, SP, Brazil

DOI:

https://doi.org/10.14295/bds.2012.v15i3.844

Abstract

The aim of this study was to investigate different periods of estrogen replacement therapy onset on the progression of experimental periodontitis in ovariectomized rats. MATERIAL AND METHODS: Sixty five female Wistar rats were ovariectomized and divided into two groups, experimental and control that received 17ß estradiol or vehicle, respectively. Each group was subdivided into five subgroups that started the treatment immediately, one, two, three and four weeks after the ovariectomy. A month after ovariectomy, a cotton ligature was placed around the maxillary second molars. Thirty five days after ligature placement, the animals were killed. It was analyzed the macroscopic, radiographic, microscopic and histometric aspects of the periodontal area. RESULTS: The results indicated that estrogen-deficient state may not have a direct effect on the alveolar bone adjacent to the maxillary second molar roots. CONCLUSIONS: Under the conditions of this experiment, estrogen replacement therapy did not delay the progression of induced periodontitis.

 

KEYWORDS: Estradiol; osteoporosis, ovariectomy; periodontal diseases.

 

Author Biographies

Marianne Spalding, Univ Estadual Paulista “Júlio de Mesquita Filho” – Campus of São José dos Campos, SP, Brazil

Departament of Bioscience and Oral Diagnosis – Dentistry School –

Priscila Ferreira Amschilnger, Univ Estadual Paulista “Júlio de Mesquita Filho” – Campus of São José dos Campos, SP, Brazil

Departament of Bioscience and Oral Diagnosis – Dentistry School

Marcela Almeida Prado, Univ Estadual Paulista “Júlio de Mesquita Filho” – Campus of São José dos Campos, SP, Brazil

Departament of Bioscience and Oral Diagnosis – Dentistry School

Ivan Balducci, Univ Estadual Paulista “Júlio de Mesquita Filho” - Campus of São José dos Campos, SP, Brazil

Department of Social Dentistry and Pediatric Clinics, Dentistry School

Yasmin Rodarte Carvalho, Univ Estadual Paulista “Júlio de Mesquita Filho” – Campus of São José dos Campos, SP, Brazil

Departament of Bioscience and Oral Diagnosis – Dentistry School

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Published

2012-12-18

Issue

Vol. 15 No. 3 (2012): Jul. - Sep. / 2012

Section

Clinical or Laboratorial Research