Alternative therapies for denture stomatitis treatment: in vivo experimental model in rats

Authors

  • Guilherme Rodrigues Teodoro Department of Environmental Engineering and Oral Biopathology Graduate Program, Institute of Science and Technology, Universidade Estadual Paulista - UNESP
  • Gabriela de Morais Gouvêa Lima Department of Environmental Engineering and Oral Biopathology Graduate Program, Institute of Science and Technology, Universidade Estadual Paulista - UNESP
  • Marina Bacelar Silva Institute of Science and Technology, Universidade Estadual Paulista - UNESP
  • Patricia Carla Lopes Institute of Science and Technology, Universidade Estadual Paulista - UNESP
  • Cybelle Mori Hiraoka Oral Biopathology Graduate Program, Institute of Science and Technology, Universidade Estadual Paulista - UNESP
  • Gabriela de Fátima Santana-Melo Department of Environmental Engineering and Oral Biopathology Graduate Program, Institute of Science and Technology, Universidade Estadual Paulista - UNESP
  • Daniel Freitas Alves Pereira Department of Environmental Engineering and Oral Biopathology Graduate Program, Institute of Science and Technology, Universidade Estadual Paulista- UNESP.
  • Fernanda Lourenção Brighenti Department of Pediatric Dentistry, Araraquara Dentistry School, Universidade Estadual Paulista- UNESP
  • Cristiane Yumi Koga-Ito Department of Environmental Engineering and Oral Biopathology Graduate Program, Institute of Science and Technology. Universidade Estadual Paulista- UNESP.

DOI:

https://doi.org/10.14295/bds.2017.v20i1.1368

Abstract

Background: Denture stomatitis (DS) is a multifactorial condition that commonly affects denture users and is mainly caused by Candida albicans. Due to the toxic effects of antifungal therapy, new therapies for DS are claimed. Objective: The aim of the study was to evaluate the efficacy of aqueous extract of Buchenavia tomentosa and sodium bicarbonate against C. albicans in a model of DS in rats. Material and Methods: An acrylic resin device simulating a denture base was fixed covering the palate of forty-eight male rats followed by candidiasis induction. Rats were divided into 4 groups (n=12): Control, sodium bicarbonate, B. tomentosa and nystatin (positive control). Each group was subdivided according to the period of treatment; 24 hours (n=6) and 48 hours (n=6). Animals were sacrificed and had their devices removed for C. albicans counts and SEM analysis. The palate mucosa was removed and processed for histopathologic analysis. Results: After 24 hours of treatment, both B. tomentosa and nystatin groups reduced significantly C. albicans counts when compared to control (nystatin x control, p<0.01; B. tomentosa x control, p=0.03). The results were confirmed by the histologic analysis. Conclusion: Both the aqueous extract of B. tomentosa and sodium bicarbonate was able to significantly decrease C. albicans counts in an experimental model of DS.

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Author Biography

Gabriela de Morais Gouvêa Lima, Department of Environmental Engineering and Oral Biopathology Graduate Program, Institute of Science and Technology, Universidade Estadual Paulista - UNESP

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Published

2017-03-29

How to Cite

1.
Teodoro GR, Lima G de MG, Silva MB, Lopes PC, Hiraoka CM, Santana-Melo G de F, et al. Alternative therapies for denture stomatitis treatment: in vivo experimental model in rats. BDS [Internet]. 2017 Mar. 29 [cited 2025 Oct. 7];20(1):70-9. Available from: https://ojs.ict.unesp.br/index.php/cob/article/view/1368

Issue

Vol. 20 No. 1 (2017): Jan. - Mar. / 2017 - Published February 2017

Section

Clinical or Laboratorial Research

License

Brazilian Dental Science uses the Creative Commons (CC-BY 4.0) license, thus preserving the integrity of articles in an open access environment. The journal allows the author to retain publishing rights without restrictions.

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